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The modulation of this pathway by oxicam analog presents a promising therapeutic role (154, 155)

While PLC-1 is the direct target of miR-26b-5p (antioncogene), which can act on PLC-1 and prevent CCA metastasis ( 3.5 WNK1-TRPC6-NFATc1 pathway WNK1 in ccRCC cells regulates Ca 2+ signal by activating Gq-coupled receptor/PLC- pathway, further mediates the activation of transient receptor potential cation channel 6 (TRPC6) and up-regulates the level of NFATc1

J Trace Elem Med Biol 2015;30:153-9

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Am J Dig Dis 22:605610 Heard KJ, Green JL, James LP, Judge BS, Zolot L, Rhyee S, Dart RC (2011) Acetaminophen-cysteine adducts during therapeutic dosing and following overdose