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The drug concentration in the final assays was 10 M

Small pilot studies in women with PCOS have suggested potential benefits on insulin sensitivity and hormonal parameters, but robust, large-scale trials examining weight loss outcomes specifically are lacking

For instance, P115 and GRASP65 trigger apoptosis via the ERK/p53/PUMA pathway or Fas-mediated signaling, respectively, whereas Bruce and GAAP decrease apoptosis via caspase-9, Smac and p53 inhibition, and Ca 2+ signaling downregulation [93]

FOXA1 can promote the expression of E-cadherin, while BACH1 inhibits the expression of FOXA1 and genes critical for epithelial cell adhesion, including claudin3 and claudin4, thus promoting the EMT

Experiments were performed by trained staff blinded to clinical information