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The HSV-1 genome can be modified through genetic engineering in two main ways: first, by reducing infectivity and toxicity to normal cells via limited replication and assembly, altered protein-virus receptor binding, and minimized immune evasion

CMS did not, contrary to the commenter's understanding, propose defining or deeming them to be primary care providers. Additionally, the primary care services provided by physician assistants, nurse practitioners, and clinical nurse specialists have been used in the Shared Savings Program assignment methodology ( 425.402) since the inception of the program

Current research on 5-Amino-1MQ focuses on short-to-medium-term use in controlled settings

The preservative-based formulation allows practitioners to prepare multiple doses from a single vial during a treatment session or across multiple appointments, improving workflow efficiency and cost management

We also acknowledge commenters' other concerns, including whether we have the statutory authority to impose BFSF standards that conflict with MDRP and the FMV requirements conflict with FMV frameworks under other law in our purview