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I long recognized that people would come to me saying, "I ran all the labs and everything looks fine." And I'd look at the same labs and see early insulin resistance

Key points: Both medications cause similar gastrointestinal side effects, most commonly nausea, diarrhoea, and constipation Side effects tend to occur early in treatment and improve over time Tirzepatide appears to have lower discontinuation rates due to side effects than liraglutide Liraglutide has a longer safety track record (approved 2015 vs 2023 for tirzepatide) Dosing and practical differences Injection frequency One of the most significant practical differences is how often you inject