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Mucus secretion includes bicarbonate, which helps maintain a neutral pH at the epithelial surface, while surfactant phospholipids serve as a physical barrier alongside luminal digestive enzymes [6]

doi: 10.1002/ana.24510

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cerebrovascular damage, characterized by microinfarcts, amyloid angiopathy, or endothelial dysfunction disrupting the bloodbrain barrier (BBB) integrity