Carriers of certain alleles may experience greater reductions in HbA1C and body weight, while others may have attenuated responses or increases risk of GI side effects [14,66,133,135,136]
In the STEP 1 trial published in The New England Journal of Medicine , people taking semaglutide lost more than 15% of their body weight over about 16 months
While they may work differently, tirzepatide and semaglutide both share common digestive side effects, like: Other side effects may include: Dr
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Lancet Diabetes Endocrinol 3(5):367381 van Bommel EJM, Muskiet MHA, Tonneijck L, Kramer MHH, Nieuwdorp M, van Raalte DH (2017) SGLT2 inhibition in the diabetic kidneyfrom mechanisms to clinical outcome