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[1] [3] This medication works through several complementary mechanisms to support weight loss: Appetite regulation : Semaglutide acts on receptors in the brain's appetite centres, particularly in the hypothalamus, reducing hunger signals and increasing feelings of satiety [1] [3] Delayed gastric emptying : The medication slows the rate at which food leaves the stomach, prolonging the sensation of fullness after eating (though this effect may diminish somewhat with long-term use) Improved glycaemic control : Semaglutide enhances glucose-dependent insulin secretion and suppresses inappropriate glucagon release, helping to stabilise blood sugar levels [1] [3] These mechanisms make Wegovy effective for weight management, but they also explain why dietary choices remain crucial