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In vivo experiments Experiments involving animals were approved by the Italian Ministry of Health and have been done in accordance with the applicable Italian laws (D.L.vo 26/14 and following amendments), the Institutional Animal Care and Use Committee, and the institutional guidelines at the European Institute of Oncology

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Barbe et al., 2019)

The most widely used ones right now are semaglutide (sold as Ozempic for diabetes management and Wegovy for weight loss) and tirzepatide, which targets both GLP-1 and a second hormone called GIP (Mounjaro for diabetes, Zepbound for weight loss)

Additionally, GGCT knockdown concomitantly reduced 5- oxoproline (5-OP) levels in MHCC97H cells, consistent with 5-OP being the direct enzymatic product of GGCT activity, and exogenous 5-OP rescued proliferation under Gln-deprived conditions (Fig