The quality of available evidence is further limited by methodological concerns, including small sample sizes, short study durations, lack of standardisation in probiotic formulations, and potential publication bias favouring positive results
Common symptoms of SFN include: Burning pain, typically beginning in the feet and sometimes spreading to the hands Sharp, shooting, or electric-like pain Numbness and tingling Allodynia (pain from normally non-painful stimuli, like light touch) Hyperalgesia (increased sensitivity to pain) Autonomic symptoms such as abnormal sweating, blood pressure fluctuations, digestive issues, and bladder dysfunction Skin changes in affected areas SFN can be particularly challenging to diagnose because standard nerve conduction studies, which are commonly used to evaluate peripheral neuropathies, primarily assess large fiber function and often miss small fiber damage
doi: 10.1007/s11064-017-2281-1 158 ZhangY
These unapproved products pose additional risks for people attempting to microdose
This puts the consumer at risk for paying for poor products
