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The primary evidence regarding tirzepatide's cancer risk comes from the SURPASS clinical trial program for type 2 diabetes and the SURMOUNT trials for weight management

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Zepbound has FDA-reviewed labeling and manufacturing

The peptide is further modified with a fatty diacid moiety (via a linker), which is commonly evaluated in research on peptide stability, distribution behavior, and extended exposure profiles

Long-term watch items beyond the common GI events that fade within weeks include gallbladder disease (cholelithiasis 1.1% in trials), acute kidney injury (0.5%), and rare cases of pancreatitis (under 1%)