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This transition was driven by landmark trials, including ELIXIA (Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 [Lixisenatide]), 23 LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results), 24 EXSCEL (Exenatide Study of Cardiovascular Event Lowering Trial), 30 HARMONY OUTCOMES (Effect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus), 38 and REWIND (Researching Cardiovascular Events With a Weekly Incretin in Diabetes), 37 which demonstrated significant reductions in MACE among patients with DM at high CV risk

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The fat debris is subsequently cleared through the lymphatic system

Nature 307 : 462465

Comparison of pioglitazone and gliclazide in sustaining glycemic control over 2 years in patients with type 2 diabetes