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The researchers also emphasised the critical role of gut microbiota dysbiosis in obesity, prompting the evaluation of microbiota-remodelling strategies such as pro-, pre- or synbiotic therapy

Although the translation of these findings to pediatrics is unclear, a metaanalysis of five randomized controlled trials and one cohort study involving 2071 adults demonstrated significant improvements in depressive symptoms with GLP1As [5]

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It was a very well-run set of trials that gave us a clear answer. At this early stage of the disease, semaglutide was not enough to slow Alzheimers progression, she says