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(Folate deficiency disrupts normal DNA synthesis and methylation, which interferes with cell division and development, especially in rapidly dividing embryos.) Megaloblastic anemia, which can lead to symptoms like fatigue, weakness, and difficulty concentrating Elevated homocysteine, even when B12 levels are normal

found that anti-inflammatory bacterial groups such as Bacteroides and the Clostridium leptum subgroup are reduced in those diagnosed with depression (Mason et al., 2020), suggesting that gut dysbiosis, especially the decrease of these anti-inflammatory regulatory bacteria, plays an important role in the pathophysiology of depression

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Evidence showed, as mentioned, wide therapy counteracting potential (NO-release, NO-synthase (NOS)-inhibition (L-NAME), NOS-over-activity (L-arginine), NO-system immobilization (L-NAME+L-arginine)

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