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Ephrins and Eph receptors are involved in several processes that occur during embryogenesis including vascular development, tissue-border formation, cell migration and axon guidance [156, 157]

Aggarwal B, Swisher SG , Hunt K, Jr P, JB, Ajani J, Komaki RR, Molke KL, Lehman J, Bismark M, Walsh GL, Correa AM, Ho L, Liao Z, Lynch P, Rice D, Smythe WR, Stevens C, Vaporciyan AA, Yao J, Roth JA

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however, including a control tube can mitigate this effect