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One is that they have lost a lot of market share in the U.S., which is the biggest pharmaceutical market in the world

Starting on lower doses and titrating slowly reduces the risk of nausea and other gastrointestinal effects

Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: a systematic analysis of published clinical trials

Secondly Retatrutide is not marketed in pharmaceuticals: it exists in Phase 3 at Eli Lilly, without marketing authorization or European or American market access