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Important precautions include: GLP-1 receptor agonists should not be used in patients with type 1 diabetes or diabetic ketoacidosis Caution is advised in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 These medications are not recommended in severe gastrointestinal disease They should not be used during pregnancy or breastfeeding, and semaglutide should be discontinued at least 2 months before a planned pregnancy [1] [7] Your GP or specialist will assess your individual circumstances to determine suitability