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Plans could see real savings, Fendrick said, if they covered GLP-1s for initial weight loss then moved people to cheaper options -- such as more affordable drugs or behavioral health programs -- to maintain it

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Although the mechanisms leading to a blood pressure decrease during the treatment with GLP-1 agonists have not been fully elucidated it could be the result of an increased sodium and water excretion and/or inhibition of the RAAS activity 14

The therapeutic application of GLP-1 agonists for obesity is grounded in well-established physiological mechanisms that extend beyond glucose regulation to encompass appetite control and energy homeostasis