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Patients can expect to lose around 15% of their bodyweight when coupling treatment with healthy habits and sticking to their weekly injections

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Front Endocrinol (Lausanne) 14:1240263 [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Sattar N, Neeland IJ, Dahlqvist Leinhard O, Fernandez Lando L, Bray R, Linge J et al (2025) Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial

In diabetes, renal gluconeogenesis is increased and the ability to reabsorb glucose in the convoluted segment of the proximal tubule is pathologically increased via upregulation of SGLT2 transporters