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The commenters shared their belief that inherently higher costs of complex cases driven by patient severity, rather than inefficiencies or poor quality, combined with the emphasis on cost without appropriate risk adjustments, and severe financial consequences could discourage skilled specialists from participating in ASM and from providing care in resource-intensive but clinically appropriate settings like hospitals and rural facilities, ultimately limiting patient access to necessary care

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GR and GS can be stimulated even by lower concentrations (200M and 400M) indicating that glutathione metabolism in macrophages is tightly regulated in order to keep adequate GSH levels