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Description

Mechanistically, lactylation of NEDD4 at lysine 33 decreases its binding affinity with Caspase-11 and the subsequent ubiquitination of Caspase-11, leading to non-canonical pyroptosis and advancing AILI

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SHMT = serine hydroxymethyltransferase

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Mladenov M, Lubomirov L, Grisk O, Avtanski D, Mitrokhin V, Sazdova I, et al

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Ruer-Gru, D

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