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HDAC7-mediated deacetylation stabilizes PSAT1, thereby affecting serine metabolism and the sensitivity of lung adenocarcinoma (LUAD) cells to the chemotherapeutic agent cisplatin ( 5.4 Cross-regulation by signaling pathways The de novo serine synthesis pathway forms an interactive regulatory network with oncogenic signaling pathways including Akt, mTOR and EGF-ERK

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SAMe boosts hepatic levels of the antioxidant glutamine