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These comorbidities are interlinked via shared immunopathogenic mechanisms, notably chronic low-grade inflammation driven by Th1/Th17 cytokines such as TNF, IL-6, and IL-17

20% Piperidine solution (50 ml of piperidine in 200 ml of DMF) was added to the obtained reaction mixture at 25-30C and stirred for 30 min at the same temperature

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When formulated thoughtfully, this pairing offers a more resilient approach to brightening and antioxidant protection than either ingredient alone

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