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Clinical trials show Contrave produces modest weight loss (510% body weight in responders over 56 weeks), with effects primarily through central nervous system modulation rather than slowed gastric emptying or incretin hormone stimulation

Hoegberg, L., Shepherd, G., Wood, D., Johnson, J., Hoffman, R., Caravati, E., Chan, W., Smith, S., Olson, K., & Gosselin, S

Tier 3 patients often experience significant improvements in energy levels and brain fog within 2-4 weeks, with substantial weight loss and metabolic improvements within 8-12 weeks, and continued progress over 6-12 months

These signs help ensure vision is preserved and complications are avoided

Kameda T