We do now have drugs (Dononamab and Lecanemab) which show some benefit and one might consider whether these should be the placebo treatments against which new drugs are tested. Prof Paresh Malhotra , Group Leader at the UK Dementia Research Institute Care Research & Technology Centre and Head of the Division of Neurology at Imperial College London said: "These two linked trials show that, unfortunately, semaglutide appears to have no effect on progression in people with established Alzheimers disease, including people who have evidence of some damage to brain blood vessels
Medications Alternative medications may include other anti-inflammatory drugs, immunosuppressants, or biologics
These services were allowed to manufacture and sell unbranded versions of these medicines, even though they are still under patent, due to shortages of the branded versions
The only literature-reported phase 1 clinical study to date was recently conducted with PF-06882961
Trials of orforglipron and lower-dose tirzepatide suggest that if and when these drugs are licensed, they could be used to maintain weight loss after higher-dose injectable incretin therapies 45
