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This epigenetic regulation is particularly important for maintaining genomic stability and preventing aberrant gene expression during aging

Subtle cumulative changes often go unnoticed without visual reference

Astrocyte-mediated enhancement of neuronal survival is abolished by glutathione deficiency

The results were striking

Given such an extreme genetic heterogeneity, and an unequivocal role of LoF-impacted (and often haploinsufficient) genes in ASD etiology, it will be invaluable to shift from identification-based research and proceed to investigate therapeutic techniques that could increase the expression of these genes