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3 Effects of Caffeine on Pharmacokinetics and Pharmacodynamics of Antidepressants 3.1 SSRIS SSRIs are the first-line pharmacological therapy for the treatment of major depression disorders because they are the safest, are best tolerated, and have high efficacy [23]

After a 20-min incubation with immunol staining blocking buffer (Beyotime, Shanghai, China), cells were continuously incubated with mouse anti-SMA (1:100, Abcam) and rabbit anti-CD133 (1:100, Abnova) 44 at 4 C overnight

Microbiome testing, although widely available, cannot identify probiotic treatment responders so a 10-week therapeutic trial could be considered