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Alikhani et al

Additionally, after 4 weeks, the levels of glutathione and superoxide dismutase in spinal cord tissues were significantly elevated, whereas that of malondialdehyde was significantly decreased in GlyNAC-treated animals

In each of these, diagnostic biomarkers are well established and typically integrated into differential diagnosis when clinically suspected

All those findings highlight the potential of DNA-TG as a promising inclusive marker for toxicity in thiopurine-treated patients, especially those with NUDT15 variants

Early intervention significantly improves outcomes and can prevent irreversible nerve damage