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The disc is loaded with compression or shear/distraction, and nucleus pulposus tissue is lost as it herniates either through the ruptured annulus or failed annulus-endplate interface (disc injury type B1) or through the fractures lines of the endplate (disc injury type B3)

These peptides send signals in the body

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress