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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

Additionally, retatrutide significantly improved blood lipids and blood pressure compared to placebo

The effect of kidney disease, in particular, is quite pronounced: pre-dialysis patients may have twice the level of TMAO, and hemodialysis patients may have 10 times the level of TMAO as otherwise healthy patients

Homemade protein shakes can be a great way to add in fruits like banana, berries and melon, as well as veggies like spinach

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