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Recent advances in Nrf2 activators, such as synthetic triterpenoids and natural compounds, highlight the need for temporal precisionactivating Nrf2 early to preserve -cell function but avoiding chronic overexpression, which may promote cancer (Mohamadi et al., 2023)

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Tirzepatide, by contrast, activates both GIP and GLP-1 receptors in the brain and pancreas, signaling satiety and reducing hunger hormones like ghrelin

& Wanasundara, J