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It is derived from octanoic acid and is transported into the cells where it is rapidly reduced to dihydrolipoic acid (DHLA), the more bioactive form of alpha lipoic acid, which possesses the unique ability to neutralise free radicals

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Jos Esprito Santo, Lote 49, Loja 1, Chelas, 1900-672 LISBOA, PORTUGAL Telephone: + 351-218371699 Fax: + 351-218371712 E-mail: [email protected] Acknowledgements This article is based on a paper presented at the International Conference on Chromosome 21 and Medical Research on Down Syndrome, Barcelona, 1997

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The null phenotypes and moderated phenotypes lack the protective benefit against ASD and other psychiatric illnesses