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Description

In PIONEER 5 in patients with moderate renal impairment, and PIONEER 8 in patients receiving insulin, oral semaglutide was superior to placebo for reducing HbA 1c and body weight at week 26 [9, 11]

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Bariatric surgery produces average weight loss of 25 to 35% depending on the procedure

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So when theres less muscle, metabolism slows

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