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Combining medications requires sterile compounding conditions

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95% CI, 0.501.03) (85)

If needed, unopened pens may be kept at 46F to 86F (8C to 30C) for up to 28 days before use [1] Keep pen cap on when not in use to protect from light Do not store with needle attached (may cause leakage or air bubbles) For patients using compounded semaglutide products, which are not FDA-approved, storage requirements are determined by the compounding pharmacy based on USP standards

The risk of such an event was 24% lower in the semaglutide group than in the placebo group (331 vs 410 first events