Additionally, identifying dual-function molecular regulators using large-scale population-based multi-omics datasets could enable the discovery of shared biomarkers and therapeutic targets
We conclude that allosteric targeting has great potential for further expansion in drug delivery research
Liu J, Ghaziani TT, Wolf JL
recently reported the GLP-1 analogue liraglutide ameliorates MG-induced cytotoxicity and apoptosis in human neuroblastoma cell SH-SY5Y through enhanced expression of pro-survival Mcl1 signaling protein, activation of Akt, MEK1/2, and transcription factor p90RSK 12
GLP-2R+ myofibroblasts in the small intestine and colon contain keratinocyte growth factor (KGF), whereby immunoneutralization of KGF abolishes the trophic effects of GLP-2 treatment in the colon, but not the small intestine in mice (Orskov et al., 2005)