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Similarly, cyclosporine and methotrexate are effective in reducing inflammation but are associated with significant risks, including nephrotoxicity, hypertension, and hepatotoxicity, limiting their long-term use [94]

Clinically, steady state often correlates with a stabilization of side effects

A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice

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Surgical cases typically require a few weeks to a few months for full healing