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Data availability The datasets generated in this study, including previously published RNA sequencing raw data, are available in the Mendeley Data repository ( with DOI: 10.17632/5hd3f79d6m.1

Folic acid remains an effective way to support one-carbon metabolism and lower homocysteine in most people, while methylfolate may offer advantages for some individuals, particularly those with reduced DHFR activity or a poor response to folic acid

Nutricion Hospitalaria , 28 (Suppl 5), 2131

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These studies found that the amount of time spent in the sauna also affected cardiovascular-related mortalities, with a longer duration of 19 minutes or more having a more robust effect than 11 to 18 minutes on lowering the mortality rate