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Released in response to nutrient intakeparticularly carbohydrates and fatsGLP-1 plays a central role in glucose homeostasis and metabolic regulation

The core patent Novo first filed for semaglutide in March 2006 is expiring in countries where no extension was granted, with Canada the first to lose protection after missed maintenance fee payments

Long-acting GLP-1RAs The long-acting GLP-1RAs are exenatide extended-release (once weekly), liraglutide (once daily), dulaglutide (once weekly) and semaglutide (once weekly injections or once daily oral administration)

[13] [15] Administered as a once-weekly subcutaneous injection, tirzepatide is available in escalating doses from 2.5 mg to 15 mg

Stephen C