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10.1056/NEJMoa1506362 [DOI] [PMC free article] [PubMed] [Google Scholar] 127.Zeier M, Reiser J

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Different hypotheses are considered, including a compensatory relationship between incretin receptors by which GIPR enhances GLP-1R activity and/or that chronic GIPR agonism produces desensitisation and loss of GIPR activity, thus, mimicking antagonism

So the practical message is fairly straightforward