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8.5 Geriatric Use No patients above the age of 65 years were enrolled in double-blind prospective clinical trials of mania associated with bipolar illness

Rosenblatt DS (1995)

Supplemental citrulline is more efficient than arginine in increasing systemic arginine availability in mice

It plays integral roles in: Immune regulation Cancer suppression (anti-proliferative and pro-apoptotic signaling) Mitochondrial function and redox balance Hormonal feedback loops, including cortisol and estrogen/testosterone rhythms Aging diminishes melatonin output by up to 75%, leading to weaker circadian cues and downstream systemic dysfunction

PMID: 19 SeoG-YTakahashiDWangQMikulskiZChenAChouT-Fet al