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The within-individual variation from dose to dose in oral semaglutide bioavailability was relatively high, but as a result of daily dosing and a long plasma half-life (1 week), the variability of semaglutide exposure at steady state was considerably reduced

Ischemic colitis, reduced blood flow to the colon, produces sudden abdominal pain and bloody stools, typically in older adults with vascular disease

This can increase the chances of leg cramps, particularly during physical activity or at night when blood flow naturally slows down

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Also, storing semaglutide vials or pens near a window with direct sunlight exposure can lead to quick temperature increases that jeopardise its stability