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Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)
A GST monomer binds a glutathione molecule to its N-terminal glutathione-binding site
Neuron 68 , 857864 (2010)
In the unlikely event of significant copper toxicity, treatment involves IV chelation therapy using EDTA, which binds to excess copper and allows it to be excreted through the kidneys
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