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The FDA declared the tirzepatide shortage over in December 2024 and the semaglutide shortage over in February 2025 which should have ended pharmacies' ability to legally compound "copy" versions of the drugs, according to FDA guidance

No small talk

Suppress Glucagon Release Glucagon is a hormone that raises blood sugar by signaling the liver to release stored glucose

Semaglutide, by contrast, activates GLP-1 receptors in the pancreas and brain to reduce appetite, slow gastric emptying, and improve insulin sensitivity

"This approval brings another important treatment option to people living with obesity," Novo Nordisk Chief Executive Mike Doustdar said in a statement, adding that a tablet may be simpler and more acceptable for some patients than injections