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Summary Glycocalyx degradation in SAP is not limited to a single organ but represents a systemic vascular endothelial insult, resulting from widespread inflammatory and enzymatic activation

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usually with a more rapid onset (115)

Thus, these results showed a strong glucose-lowering effects towards a nearly-normal range with weight loss of a not previously reported extent in people with T2DM and without increased risk of clinically significant hypoglycemia [24]