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The first step consists in the introduction of a double bond between the C2 and C3 by the enzyme acyl-CoA-dehydrogenase to produce a trans -2-enoyl-CoA while flavin adenine dinucleotide (FAD) is reduced to FADH 2

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As a triple agonist targeting GLP-1, GIP, and GCG receptors, retatrutride represents an advanced approach to managing type 2 diabetes and obesity

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