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Die pathohistologischen Untersuchungen sowohl der akuten als auch chronischen Toxizitt ergaben, dass L-NAME schwere Gewebeschden (myokardiale und hepatische Zellnekrose und Nekrose der Lymphoidzellen in der Milz) verursachte, whrend L-Arginin vorwiegend Kongestion, dem und Hmorrhagien in smtlichen Organen hervorrief