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NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40
Figure 1 All zDHHC-PATs share a common DHHC motif to mammals, and is the catalytic core of the enzyme
10.1111/dom.13172 67 WangY.ParlevlietE
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