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3 One study (an extension of the original STEP-1 trial) also showed that participants regained two-thirds of their weight after discontinuing semaglutide, suggesting that maintaining weight loss may require long-term use

Neither semaglutide nor tirzepatide has a clinically significant safety advantage over the other, though nausea and gastrointestinal effects occur in both

Eli Lilly, the makers of Zepbound, gained FDA approval for its drug orforglipron, sold under the brand name Foundayo, on April 1, 2026, following Novo Nordisk, which received approval for the Wegovy pill in December 2025

Critically, all three impurities exhibit high reactivity with the P29 peptide, thereby becoming transferred impurities in the final semaglutide API

He has also become aware of his proneness to emotional eating