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Gastrointestinal symptoms dominate the side effect profile

and a single-layered hamster cheek pouch preparation, which allowed direct observation of changes in arteriolar diameter in the in situ microcirculation in an animal model previously shown to be especially vulnerable to oxidative stress and microvascular dysfunction when consuming a high salt diet [41]

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Full microbiome restoration the phase where beneficial bacteria are re-established at protective levels and the gut lining is fully repaired generally takes three to six months