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It is worth to note that the C347K mutated receptor is G-protein biased for the non-fused EX4 ligand but is unbiased when EX4 is fused to the receptor (Figures 4c, d and 5a, b), suggesting that biased and unbiased signaling are very sensitive to receptor context and to the fused/unfused status of EX4 peptide

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This method ensures rapid absorption, especially for individuals with absorption issues