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Such profound weight loss is attributed to its ability to significantly reduce appetite, leading to decreased caloric intake, coupled with its effects on energy expenditure and improved glycemic control

This limitation has direct clinical implications, as treatment decisions frequently involve dose escalation or switching between agents in the absence of head-to-head evidence

Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine , 2021

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Patients may be more likely to switch to eating healthy foods if their tastes are different.